[HTML][HTML] Effect of reducing ataxia-telangiectasia mutated (ATM) in experimental autosomal dominant polycystic kidney disease
JQJ Zhang, S Saravanabavan, GK Rangan - Cells, 2021 - mdpi.com
The DNA damage response (DDR) pathway is upregulated in autosomal dominant
polycystic kidney disease (ADPKD) but its functional role is not known. The ataxia-
telangiectasia mutated (ATM) and AT and Rad3-related (ATR) protein kinases are key
proximal transducers of the DDR. This study hypothesized that reducing either ATM or ATR
attenuates kidney cyst formation and growth in experimental ADPKD. In vitro,
pharmacological ATM inhibition by AZD0156 reduced three-dimensional cyst growth in …
polycystic kidney disease (ADPKD) but its functional role is not known. The ataxia-
telangiectasia mutated (ATM) and AT and Rad3-related (ATR) protein kinases are key
proximal transducers of the DDR. This study hypothesized that reducing either ATM or ATR
attenuates kidney cyst formation and growth in experimental ADPKD. In vitro,
pharmacological ATM inhibition by AZD0156 reduced three-dimensional cyst growth in …
[PDF][PDF] Effect of Reducing Ataxia-Telangiectasia Mutated (ATM) in Experimental Autosomal Dominant Polycystic Kidney Disease. Cells 2021, 10, 532
JQJ Zhang, S Saravanabavan, GK Rangan - 2021 - academia.edu
The DNA damage response (DDR) pathway is upregulated in autosomal dominant
polycystic kidney disease (ADPKD) but its functional role is not known. The ataxia-
telangiectasia mutated (ATM) and AT and Rad3-related (ATR) protein kinases are key
proximal transducers of the DDR. This study hypothesized that reducing either ATM or ATR
attenuates kidney cyst formation and growth in experimental ADPKD. In vitro,
pharmacological ATM inhibition by AZD0156 reduced threedimensional cyst growth in …
polycystic kidney disease (ADPKD) but its functional role is not known. The ataxia-
telangiectasia mutated (ATM) and AT and Rad3-related (ATR) protein kinases are key
proximal transducers of the DDR. This study hypothesized that reducing either ATM or ATR
attenuates kidney cyst formation and growth in experimental ADPKD. In vitro,
pharmacological ATM inhibition by AZD0156 reduced threedimensional cyst growth in …
