[HTML][HTML] Distinct roles for Rho versus Rac/Cdc42 GTPases downstream of Vav2 in regulating mammary epithelial acinar architecture
Non-malignant mammary epithelial cells (MECs) undergo acinar morphogenesis in three-
dimensional Matrigel culture, a trait that is lost upon oncogenic transformation. Rho
GTPases are thought to play important roles in regulating epithelial cell-cell junctions, but
their contributions to acinar morphogenesis remain unclear. Here we report that the activity
of Rho GTPases is down-regulated in non-malignant MECs in three-dimensional culture
with particular suppression of Rac1 and Cdc42. Inducible expression of a constitutively …
dimensional Matrigel culture, a trait that is lost upon oncogenic transformation. Rho
GTPases are thought to play important roles in regulating epithelial cell-cell junctions, but
their contributions to acinar morphogenesis remain unclear. Here we report that the activity
of Rho GTPases is down-regulated in non-malignant MECs in three-dimensional culture
with particular suppression of Rac1 and Cdc42. Inducible expression of a constitutively …
